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F8 gene analysis / Immunogenotyping / HLA genotyping

J. Oldenburg and A. Pavlova will investigate the impact of genetic risk factors (gene defect responsible for haemophilia and several immune response genes) on the course and outcome of ITI.

Hypothesis:

Host genetic factors as the F8 gene defect or polymorphism of the immune response genes might act as predictors of the ITI outcome.

Method:

For this analysis DNA will be extracted from EDTA blood in the laboratory of J. Oldenburg in Bonn. The following genetic factors will be investigated:

Literature overview:

Johannes Oldenburg Johannes Oldenburg
Bonn, Germany
Anna Pavlova Anna Pavlova
Bonn, Germany